Dose‐dependent inactivation of Plasmodium falciparum in red blood cell concentrates by treatment with short‐wavelength ultraviolet light

• DOI: 10.1111/vox.13714
• Publication Date: 2024-07-25T00:04:36Z
• Authors: Swantje Fischer; Susann Zilkenat; Mona Rosse; Torsten J. Schulze; Axel Seltsam; Wiebke Handke; Bernd Lepenies; Ute Gravemann
• Keywords: Ultraviolet light; Ultraviolet

Abstract Background and Objectives Plasmodium species are naturally transmitted by Anopheles mosquitos. The parasite infects red blood cells (RBCs) can be transfused with products. In non‐endemic areas, the main risk of infection arises from travellers coming back people immigrating malaria‐endemic regions. Endemic countries face a permanent transfusion‐transmitted malaria (TTM). TTM may cause life‐threatening complications in patients dependent on donations. This study aimed to investigate efficacy falciparum inactivation RBC units treatment short‐wavelength ultraviolet C (UVC) light absence photochemical additives. Materials Methods were spiked P. density 0.1%–1% irradiated up 4.5 J/cm 2 UVC. UVC‐treated dilution series untreated controls compared over 3 weeks after irradiation. Results lowest dose 1.5 UVC led 3.1 log reduction load control. capacity was dose‐dependent. Strikingly, ≥5.3 unit reduction, which equivalent complete two out three experiments. Conclusion Pathogen previously shown effective for different bacteria viruses, but parasites concentrates not addressed until now. present provides evidence significant ‐infected RBCs light.