Transfusion efficacy of leucoreduced packed red blood cells prepared by two different methods: A randomized controlled trial in transfusion‐dependent thalassaemia patients (FUEL trial)

• DOI: 10.1111/vox.13797
• Publication Date: 2025-01-17T07:19:08Z
• Authors: Adhikarimayum Aru...; Ashish Jain; Sheetal Malhotra; Hari Krishan Dhawan; Srinivasan Peyam; Sangeeta Kumari; Ratti Ram Sharma

Abstract Background and Objectives Great variations may be observed in the haemoglobin (Hb) content of packed red blood cell (PRBC) units prepared by different methods. This study aimed to assess Hb increment thalassaemia major patients transfused with leucoreduced PRBCs (LPRBCs) two methods: (i) standard (SLPRBCs) (ii) a new method where leucoreduction whole is done first (NLPRBCs). Materials Methods prospective, randomized, controlled trial included 80 adult who were randomized into groups 40 each. Group I received SLPRBC those II NLPRBC transfusions for 3 months. Results SLPRBCs had mean (±SD) volume 275.50 ± 17.07 mL, while it was 316.46 1.42 mL NLPRBCs ( p < 0.001). The 50.60 5.12 g, that 56.98 5.92 g 2.11 0.89 g/dL, 2.48 0.88 g/dL transfusion interval 20.30 3.75 days, 21.34 5.13 days 0.045). A significant positive correlation between dose both ρ = 0.4, 0.001) 0.19, 0.011) transfusions. Conclusion significantly higher than SLPRBCs, leading better post transfusion, which potentially prolong patients.