Short‐term results of acellular porcine corneal stroma keratoplasty for herpes simplex keratitis

• DOI: 10.1111/xen.12509
• Publication Date: 2019-04-10T07:17:11Z
• Authors: Jiao Zheng; Xiaodan Huang; Yue Zhang; Yi Wang; Qiyu Qin; Lin Lin; Xiuming Jin; Ching Lam; Jinnan Zhang
• Keywords: Corneal perforation; Corneal Neovascularization; Perforation; Corneal graft; Corneal Transplant

Abstract Background Corneal transplantation is a common surgical intervention for restoring vision loss due to corneal damages. However, cultural reasons, there huge shortage of donor corneas in China. Acellular porcine stromas (APCSs) can be used as substitutes lamellar keratoplasty ulcers. This study was conducted analyze the results APCS use herpes simplex keratitis (HSK). Methods The involved HSK patients who underwent with APCSs from February 2016 October 2017 second affiliated hospital Zhejiang University. Patient data were collected at 7 days, 1 month, 3 months, 6 and last follow‐up (7‐25 months) postoperative. transparency, neovascularization, visual acuity, graft stability observed. Results Thirteen including five perforation included this study, nine deep anterior (DALK) double keratoplasty. There men four women an average age 62.5 ± 5.6 years old (ranging 52 70 old). mean postoperative duration 15.1 5.8 months 25 months). At visit, acuity improved (69.2%) compared preoperative ( P = 0.008).The grafts seven individuals (53.8%) completely transparent or slightly opaque; their transparency score had significantly before surgery 0.010). Various degrees neovascularization present 11 13 (84.6%), most gradually stabilized. Graft dissolution occurred three eyes (23.1%) during observation period, two regrafting, other one became stable after treatment. Three allograft transplantation, which encountered requested human issues despite absence adverse issues. Conclusion stroma seems effective treatment by using emergency.