Abnormal folate metabolism causes age‐, sex‐ and parent‐of‐origin‐specific haematological defects in mice

• DOI: 10.1113/jp276419
• Publication Date: 2018-07-19T11:17:29Z
• Authors: Nisha Padmanabhan; Katerina Menelaou; Jiali Gao; Alexander Anderson; Georgina E. T. Blake; Tanya Li; B. Nuala Daw; Erica D. Watson
• Keywords: MTRR; Macrocytic anemia; Macrocytosis; Methionine synthase; Megaloblastic anemia

Folate (folic acid) deficiency and mutations in folate-related genes humans result megaloblastic anaemia. metabolism, which requires the enzyme methionine synthase reductase (MTRR), is necessary for DNA synthesis transmission of one-carbon methyl groups cellular methylation. In this study, we show that hypomorphic Mtrr