T cells mediate cell non‐autonomous arterial ageing in mice

• DOI: 10.1113/jp281698
• Publication Date: 2021-06-24T05:05:02Z
• Authors: Daniel W. Trott; Daniel R. Machin; Tam T. T. Phuong; AdeLola O. Adeyemo; Samuel I. Bloom; R. Colton Bramwell; Eric S. Sorensen; Lisa A. Lesniewski; Anthony J. Donato
• Keywords: Mesenteric arteries

Increased large artery stiffness and impaired endothelium-dependent dilatation occur with advanced age. We sought to determine whether T cells mechanistically contribute age-related arterial dysfunction. found that old mice exhibited greater proinflammatory cell accumulation around both the aorta mesenteric arteries. Pharmacologic depletion or genetic deletion of in resulted ameliorated compared intact.