Exercise induces hepatosplanchnic release of heat shock protein 72 in humans

• DOI: 10.1113/jphysiol.2002.025148
• Publication Date: 2002-11-01T00:42:52Z
• Authors: Mark A. Febbraio; Peter Ott; Henning Bay Nielsen; Adam Steensberg; Charlotte Keller; Peter Krustrup; Niels H. Secher; Bente Klarlund Pe...
• Keywords: Femoral vein; Arterial blood; Venous blood

Physical exercise results in the appearance of heat shock protein (HSP) 72 circulation that precedes any increase gene or expression contracting skeletal muscle. In rodents, increases liver HSP72 and hepatosplanchnic viscera are known to release many acute phase proteins. present study, we tested hypothesis splanchnic tissue beds during exercise. Seven male subjects performed 120 min semi‐recumbent cycling at 62 ± 2 % maximal oxygen uptake. Blood samples were obtained simultaneously from a brachial artery, femoral vein hepatic prior 30, 60 Leg blood flow (LBF) was measured by thermodilution vein, (HBL) using indocyanine green dye. Net leg net balance calculated as product LBF venous‐arterial difference HBF difference, respectively. Arterial plasma only detected one subject rest but progressively appeared arterial throughout such it all (0.88 0.35 pg l −1 ; P < 0.05 compared with rest). The muscle did not, however, contribute this since there no concentration time. Rather, accounted for, least part, values increasing ( ) undetectable levels 5.2 0.2 after min. These data demonstrate tissues is responsible, for elevated systemic