Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle

• DOI: 10.1113/jphysiol.2002.036673
• Publication Date: 2003-03-15T13:55:31Z
• Authors: D Williamson; P Gallagher; M Harber; C Hollon; S Trappe
• Keywords: Adult; Male; Mitogen-Activated Protein Kinase 1; Aging; 0303 health sciences; Mitogen-Activated Protein Kinase 3; MAP Kinase Signaling System; Muscle Fibers, Skeletal; Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 90-kDa; p38 Mitogen-Activated Protein Kinases; 03 medical and health sciences; Humans; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Exercise; Aged

Graphical Abstract figure legend HCN channels play an evolutionarily conserved pacemaker role in renal pelvic smooth muscle (RPSM) of lower and higher order mammals. The function hyperpolarization-activated cation (HCN) pacemakers remains controversial. Renal trigger contractions that expel waste from the kidney, have been localized to these tissues. To date, however, mechanisms underlying RPSM activity remain elusive. was investigated both (top left) (bottom mammalian models, which exhibit divergent upper urinary tract anatomies. We performed morphological functional studies single-molecule whole-organ level showed drive activity. (boxed regions) integrated into muscular syncytium, expressed on their plasmalemma exhibited Ih ‘funny’ current conducted by channels. Critically, channel block abolished electrical peristaltic tracts. Thus, pacemakers.