Spontaneous, synchronous electrical activity in neonatal mouse cortical neurones

• DOI: 10.1113/jphysiol.2004.071621
• Publication Date: 2004-08-06T00:20:30Z
• Authors: Rebekah Corlew; Martha M. Bosma; William J. Moody
• Keywords: Cortical neurons

Spontaneous [Ca2+]i transients were measured in the mouse neocortex from embryonic day 16 (E16) to postnatal 6 (P6). On of birth (P0), cortical neurones generated widespread, highly synchronous over large areas. average, 52% participated these transients, and 20% slices, an average 80% participated. These blocked by TTX nifedipine, indicating that they resulted Ca2+ influx during electrical activity, occurred at a mean frequency 0.91 min(-1). The occurrence this activity was centred P0: E16 P2 only 15% 24% neurones, respectively, much lower frequencies both than P0. overall individual cells did not change between P2, just degree their synchronicity. onset spontaneous, correlated with increase Na+ current density before P0, its cessation decrease resting resistance after P2. This may serve variety functions neonatal nervous system.