Relative Contribution of Wall Shear Stress and Injury in Experimental Intimal Thickening at PTFE End-to-Side Arterial Anastomoses

• DOI: 10.1115/1.1428554
• Publication Date: 2002-07-27T09:03:10Z
• Authors: Francis Loth; Steven A. Jones; Christopher K. Za...; Don P. Giddens; Raja F. Nassar; Seymour Glagov; Hisham S. Bassiouny
• Keywords: Pulsatile flow; Electrical conduit; Intimal hyperplasia; Surgical anastomosis

Background : Intimal hyperplastic thickening (IHT) is a frequent cause of prosthetic bypass graft failure. Induction and progression IHT thought to involve number mechanisms related variation in the flow field, injury nature conduit. This study was designed examine relative contribution wall shear stress induction at defined regions experimental end-to-side anastomoses. Methods Results: The distribution determined distal anastomosis seven canine Iliofemoral PTFE grafts after 12 weeks implantation. An upscaled transparent model constructed using vivo anastomotic geometry, 24 axial locations from laser Doppler anemometry measurements near velocity under conditions pulsatile similar that present vivo. computer assisted morphometry. involving native artery ranged 0.0±0.1 mm 0.05±0.03 mm. A greater amount found on hood (PTFE) 0.09±0.06 0.24±0.06 Nonlinear multivariable logistic analysis used as function reciprocal stress, distance suture line, vascular conduit type (i.e. versus host artery). Vascular line independently contributed IHT. inverse correlation between only for those located juxta-anastomotic graft. Conclusions: data are consistent with intimal which pannus migrating enhanced by reduced levels graft/host interface. Such hemodynamic modulation induced absent neighboring wall.