Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts

• DOI: 10.1117/1.nph.2.3.035004
• Publication Date: 2015-08-04T18:30:58Z
• Authors: Wesley B. Baker; Ashwin B. Parthas...; Tiffany S. Ko; David R. Busch; Kenneth Abramson; Shih-Yu Tzeng; Rickson C. Mesquita; Turgut Durduran; Joel H. Greenberg; David K. Kung; Arjun G. Yodh
• Keywords: SIGNAL (programming language); Modulation (music)

We introduce and validate a pressure measurement paradigm that reduces extracerebral contamination from superficial tissues in optical monitoring of cerebral blood flow with diffuse correlation spectroscopy (DCS). The scheme determines subject-specific contributions to the DCS signal by utilizing probe modulation induce variations flow. For analysis, head is modeled as two-layer medium probed long short source-detector separations. Then combination modified Beer-Lambert law for enables experimenters linearly relate differential signals variation without priori anatomical information. demonstrate algorithm's ability isolate during finger-tapping task graded scalp ischemia healthy adults. Finally, we adapt algorithm ameliorate oxygenation volume near-infrared spectroscopy.