Observations of the incidence of metastasis following laser hyperthermia in combination with chemotherapy, PDT, and excision

• DOI: 10.1117/12.136997
• Publication Date: 2004-12-16T10:12:51Z
• Authors: Mianjing Wang; Menglin Gao; Jin Gao; Kexun Xue; Zuyan Xu; Jingyuan Zhang; Qongru Li; Zifan Geng; Zhuo Gong; Qing Ye; Pei Gu; Jing-Lian Xao

ABSTRACT Our early otervations have xnfirm& that laeer hyperthermia or PDT along do not promote the tumor metastasig. In order to evaluate the combined effect of local tumor laaer hyperthermia on thedistant metastasia, transplantable foreetomach carcinoma (Pc) in 616 line mice were treated by Nd:YAGtaaer hyperthermia (45 C/2Omin) combined with PIYT (HPIbng/kg, 48OJ/cm,2Omin), chemotherapy(CyclophoBphamide 28.8mg/kg) and excielon reepectively. The ru1ts showed that 1). the tumor growthin:hmition by various treatment wae significant compared with control group;, 2). no otatiticedifferent in metastasie rate wae obeerved in laser hyperthermia combined with PDT, chemotherapy orscalpel excision separately. It is suggest that laser hyperthermia xnnbined with PDT, chemotherapy orexcieion does not increaee the incidence of the tumor metastiwi. INTRODUCTION The nwnber of group doing reeearch in the field of laser induced hyperthermia is eteadyingincreasing in recent yeare. Due to the potential localization and control of the heating, title newmethods has led to the revival of clinical intereat in hyperthermia. The clinical studi, treatingpatienta with advanced diaeaee, have been encouraging in china.1_n considering any new form of cancer therapy, including hyperthermla, It ie Important to determinewhether the treatment iteelf might course any undirab1e side effects, such as an increaee or changein the pattern of metaetatic spread.Many metastaeis data, involving hyperthermia alone and those where some adjunctive treatment hasbeen applied, have been presented in literature.a hyperthermia appeared to enhance the