High-content multimodal in vivo imaging using a parallelized gigapixel scale microscope

• DOI: 10.1117/12.3002079
• Publication Date: 2024-03-12T22:48:12Z
• Authors: Xi Yang; Aurélien Bègue; Mark Harfouche; Clare Cook; Kanghyun Kim; Kevin C. Zhou; Roarke Horstmeyer
• Keywords: Content (measure theory)

We introduce an innovative MCAM architecture using a 6x8 array of 48 lenses and sensors for simultaneous 0.624 gigapixel imaging within few centimeters, delivering near-cellular resolution. This enables 3D video recording radiometric fluorescence organisms stereoscopic capture appropriate filters. Such feature proves advantageous when conducting combined investigations into organism behavior functional measurements. Moreover, the is equipped to perform birefringent by incorporating suitable polarizers. demonstrate multimodal capacity this system variety specimens, notably Drosophila, zebrafish.