Near-infrared imaging for intraoperative evaluation of allograft viability and function in human kidney transplantation

• DOI: 10.1117/12.3003340
• Publication Date: 2024-04-10T14:16:16Z
• Authors: Arshdeep Khurana; Christopher Nguan; Kourosh Afshar; Purang Abolmaesumi; Babak Shadgan
• Keywords: Machine Perfusion; Parenchyma

End-stage renal disease (ESRD) is a serious medical condition characterized by an irreversible decline in kidney function. The optimal treatment for ESRD transplantation, providing improved quality and quantity of life lower mortality rates compared to other treatments. While there exists vast constellation variables that contribute the ultimate success transplant, timely diagnosis allograft dysfunction its underlying etiology crucial informing appropriate plans improving graft survival rates. monitoring early postoperative function may involve regular bloodwork testing, percutaneous biopsy, intermittent transabdominal ultrasonography, all which have inherent limitations risks. Objective intraoperative assessment perfusion characteristics lacks reliable safe techniques transplantation. We propose applying novel optical technique based on near-infrared imaging (NIRI) interrogation metabolic objectives this study were examine feasibility functionality non-contact, non-invasive, handheld NIRI device hemodynamics oxygenation during Intraoperative parenchyma tissue oxygen saturation (StO₂) was performed 25 transplants. Images taken at back table after preparation, in-situ before perfusion, earliest convenience reperfusion, then 1, 2, 3, 4, 5, 10, 15, 20, minutes following reperfusion. A final image closure. digitally segmented average parenchymal StO₂ calculated each time point. All patients showed low images with increase seen clamp removal. Our demonstrated For future studies, clinical measures, additional hemodynamic parameters, such as velocity reaching max StO₂, will be donor kidneys varying quality.