SU‐F‐T‐202: An Evaluation Method of Lifetime Attributable Risk for Comparing Between Proton Beam Therapy and Intensity Modulated X‐Ray Therapy for Pediatric Cancer Patients by Averaging Four Dose‐Response Models for Carcinoma Induction

• DOI: 10.1118/1.4956339
• Publication Date: 2016-07-05T20:55:41Z
• Authors: M Tamura; Y Ito; H Sakurai; M Mizumoto; S Kamizawa; S Murayama; H Yamashita; S Takao; R Suzuki; H Shirato
• Keywords: Cumulative dose

Purpose: To examine how much lifetime attributable risk (LAR) as an in silico surrogate marker of radiation‐induced secondary cancer would be lowered by using proton beam therapy (PBT) place intensity modulated x‐ray (IMXT) pediatric patients. Methods: From 242 patients with cancers who were treated PBT, 26 selected random sampling after stratification into four categories: a) brain, head, and neck, b) thoracic, c) abdominal, d) whole craniospinal (WCNS) irradiation. IMXT was re‐planned the same computed tomography region interest. Using dose volume histogram (DVH) PBT IMXT, LAR Schneider et al. calculated for patient. The published dose‐response models carcinoma induction: i) full model, ii) bell‐shaped iii) plateau ix) linear model tested organs at risk. In case that more than one available, this patient averaging each model. Results: Calculation LARs based on DVH feasible all mean±standard deviation cumulative difference between categories 0.77±0.44% (n=7, p=0.0037), 23.1±17.2%,(n=8, p=0.0067), 16.4±19.8% (n=8, p=0.0525), 49.9±21.2% (n=3, p=0.0275, tailed t‐test), respectively. significantly lower neck region, thoracic Conclusion: had undergone estimated modeling. This method suggested to useful induced different radiotherapy techniques. research supported Translational Research Network Program, JSPS KAKENHI Grant No. 15H04768 Global Institution Collaborative Education (GI‐CoRE), Hokkaido University, founded Ministry Education, Culture, Sports, Science Technology (MEXT), Japan.