Modeling subharmonic response from contrast microbubbles as a function of ambient static pressure

• DOI: 10.1121/1.3552884
• Publication Date: 2011-04-09T00:58:02Z
• Authors: Amit Katiyar; Kausik Sarkar; Flemming Forsberg
• Keywords: Ambient pressure; Subharmonic; Natural frequency

Variation of subharmonic response from contrast microbubbles with ambient pressure is numerically investigated for non-invasive monitoring organ-level blood pressure. Previously, several both in vitro and vivo registered approximately linear (5–15 dB) reduction 188 mm Hg change In contrast, simulated a single microbubble seen here to either increase or decrease This shown using the code BUBBLESIM encapsulated microbubbles, then underlying dynamics free bubble model. The ratio excitation frequency natural determining parameter—increasing increases thereby changing this ratio. For below lower critical value, increasing monotonically decreases response. Above an upper value same ratio, response; between, variation non-monotonic. precise values these three different trends depend on radius amplitude. modeled pressure, when one happens, only certain range levels. Possible reasons discrepancies between model previous experiments are discussed.