Stable inertial cavitation with a confocal ultrasonic device for drug release from nongaseous sonosensitive liposomes

• DOI: 10.1121/1.4708121
• Publication Date: 2012-04-18T13:50:24Z
• Authors: Cyril Lafon; Jean-Louis Mestas; Jacqueline Ngo; Lucie Somaglino; Jean-Martial Mari; Sabrina Chesnais; Esben Nilssen; Jean-Yves Chapelon

Encapsulating chemotherapeutic agents in liposomes improves targeting and efficacy of treatments against some tumors. The present work aims at evaluating if sonosensitive combined with cavitation for drug delivery enhance reduce toxicity. Two focused beams were stabilizing the cloud an imaging probe used guidance. Each 1MHz transducer had a 5cm diameter focal length. Exposure conditions 10.8kW/cm2 Isppa, 250Hz PRF 1% duty cycle. Phosphatidylcholine-based nongaseous loaded Doxorubicin. To control mechanical tissue damage, AT2 Dunning tumors on rats first exposed to ultrasound only. Treatment induced temperature rose below 0.5° C. tumor growth was not significantly slowed down by ultrasound, but histological examination evidenced large areas necrosis which resorbed one week after ultrasound. new compared conventional HSPC-based terms toxicity same model. Ultrasound led equivalent when applied liposomes, while efficient only concomitant cavitation. We confocal set-up able provide sufficient inertial release from liposome reduced systemic Eureka-labelled project (E!4056) funded NRC, FFN OSEO.