The response of phospholipid-encapsulated microbubbles to chirp-coded excitation: Implications for high-frequency nonlinear imaging

• DOI: 10.1121/1.4798677
• Publication Date: 2013-05-07T13:11:23Z
• Authors: Himanshu Shekhar; Marvin M. Doyley
• Keywords: Chirp; Nonlinear acoustics

The current excitation strategy for harmonic and subharmonic imaging (HI SHI) uses short sine-bursts. However, alternate pulsing strategies may be useful enhancing nonlinear emissions from ultrasound contrast agents. goal of this study was to corroborate the hypothesis that chirp-coded can improve performance high-frequency HI SHI. A secondary understand mechanisms govern response agents sine-burst schemes. Numerical simulations acoustic measurements were conducted evaluate a commercial agent (Targestar-P®) (10 MHz frequency, peak pressures 290 kPa). results revealed an improvement in signal-to-noise ratio by 4 14 dB, two- threefold reduction threshold with excitation. Simulations Marmottant model suggest increase expansion-dominated radial excursion microbubbles mechanism responsible stronger response. Additionally, detected wider range concentrations than Therefore, could viable approach