Ultrasonic neuromodulation of the mouse cortex increases cardiorespiratory activity

• DOI: 10.1121/1.5014727
• Publication Date: 2017-11-15T21:31:33Z
• Authors: Christian Aurup; Elisa Konofagou
• Keywords: Neuromodulation; Premovement neuronal activity

Focused ultrasound (FUS) has demonstrated its ability to modulate neuronal activity in both cortical and subcortical brain regions a noninvasive safe fashion mice, non-human primates, humans. Rodent studies have shown that ultrasonic neuromodulation (UNMOD) can elicit motor responses limbs trigger pupil dilation. Little is known about the effect of CNS on autonomic primarily due cardiorespiratory depression caused by anesthesia used. However, urethane limited effects hemodynamics. In this paper, we demonstrate UNMOD cortex increases mice. A 1.9-MHz single-element focused transducer was used apply pulsed mouse cortex. Each animal injected intraperitoneally with (1500 mg/kg), allowing for stable plane experimental efficacy window often exceeding 4 hours minimal activity. Sonications were performed grid spanning centered at Bregma skull suture heart breathing rates acquired using pulse oximeter. FUS resulted significant immediately following sonication. This study an autonomous excitatory invivo.