Development and characterization of polyurethane-based tissue and blood mimicking materials for high intensity therapeutic ultrasound

• DOI: 10.1121/10.0010385
• Publication Date: 2022-05-05T12:26:26Z
• Authors: Yunbo Liu; Subha Maruvada
• Keywords: Acoustic impedance

A polyurethane-based tissue mimicking material (TMM) and blood (BMM) for the acoustic thermal characterization of high intensity therapeutic ultrasound (HITU) devices has been developed. Urethane powder other chemicals were dispersed into either a temperature hydrogel matrix (gellan gum) or degassed water to form TMM BMM, respectively. The ultrasonic properties both including attenuation coefficient, speed sound, acoustical impedance, backscatter characterized at room temperature. conductivity diffusivity, BMM viscosity, Young's modulus also measured. Importantly, coefficient nearly linear frequency dependence, as is case most soft tissues 37 °C. Their mean values are 0.61f1.2 dB cm-1 0.2f1.1 based on measurements from 1 8 MHz using time delay spectrometry (TDS) system. Most relevant physical parameters close reported blood. These appropriate developing standardized dosimetry techniques, validating numerical models, determining safety efficacy HITU devices.