Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex

Wavenumber Basilar membrane Experimental data
DOI: 10.1121/10.0022446 Publication Date: 2023-11-28T13:27:32Z
ABSTRACT
In this study, we explore nonlinear cochlear amplification by analyzing basilar membrane (BM) motion in the mouse apex. Through vivo, postmortem, and mechanical suppression recordings, estimate how amplifier nonlinearly shapes wavenumber of BM traveling wave, specifically within a frequency range where short-wave approximation holds. Our findings demonstrate that straightforward mathematical model, depicting as modifier with strength diminishing monotonically displacement increases, effectively accounts for various experimental observations. This empirically derived model is subsequently incorporated into physics-based “overturned” framework [see Altoè, Dewey, Charaziak, Oghalai, Shera (2022), J. Acoust. Soc. Am. 152, 2227–2239] tested against additional data. results relationships established region remain valid over much broader range. Furthermore, now exclusively calibrated to data, predicts behavior opposing side partition, aligning well recent The success reproducing key features data simplicity resulting provide strong support theory amplification.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (75)
CITATIONS (2)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....