Effects of Long-term Creatine Supplementation on Liver and Kidney Functions in American College Football Players

• DOI: 10.1123/ijsnem.12.4.453
• Publication Date: 2016-08-10T11:49:08Z
• Authors: David L. Mayhew; Jerry L. Mayhew; John S. Ware
• Keywords: Creatine; Creatine Monohydrate; Liver function; Venous blood; Blood urea nitrogen; Alanine aminotransferase

The purpose of this study was to determine the effect long-term Cr supplementation on blood parameters reflecting liver and kidney function. Twenty-three members an NCAA Division II American football team (ages = 19–24 years) with at least 2 years strength training experience were divided into a monohydrate group (CrM, n 10) in which they voluntarily spontaneously ingested creatine, control ( 13) took no supplements. Individuals CrM averaged regular daily consumption 5 20 g (mean ± SD 13.9 5.8 g) for 0.25 5.6 (2.9 1.8 years). Venous analysis serum albumin, alkaline phosphatase, alanine aminotransferase, aspartate bilirubin, urea, creatinine produced significant differences between groups. Creatinine clearance estimated from not significantly different Within group, correlations all either dosage or duration nonsignificant. Therefore, it appears that oral has detrimental effects functions highly trained college athletes absence other nutritional