Supplementation with β-Hydroxy- β-Methylbutyrate (HMB) and α-Ketoisocaproic Acid (KIC) Reduces Signs and Symptoms of Exercise-Induced Muscle Damage in Man

• DOI: 10.1123/ijsnem.15.4.413
• Publication Date: 2016-08-10T12:34:35Z
• Authors: Ken A. van Someren; Adam J. Edwards; Glyn Howatson
• Keywords: Muscle protein; Signs and symptoms

This study examined the effects of β-hydroxy-β-methylbutyrate (HMB) and α-ketoisocaproic acid (KIC) supplementation on signs symptoms exercise-induced muscle damage following a single bout eccentrically biased resistance exercise. Six non-resistance trained male subjects performed an exercise protocol designed to induce two separate occasions, dominant or non-dominant arm in counter-balanced crossover design. Subjects were assigned HMB/KIC (3 g HMB 0.3 acid, daily) placebo treatment for 14 d prior One repetition maximum (1RM), plasma creatine kinase activity (CK), delayed onset soreness (DOMS), limb girth, range motion (ROM) determined pre-exercise, at 1h, 24 h, 48 72 h post-exercise. DOMS percentage changes 1RM, ROM all changed over period ( P < 0.05). attenuated CK response, decrement increase girth In addition, was reduced post-exercise 0.05) treatment. conclusion, KIC males