Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria

• DOI: 10.1124/dmd.117.076612
• Publication Date: 2017-06-24T00:55:30Z
• Authors: Flora Scott; Sandra G. Gonzale...; Brett A. O’Brien; Diede Fennema; Sunil Veeravalli; Clarissa R. Coveney; Ian R. Phillips; Elizabeth A. Shep...
• Keywords: Homeostasis; Resistin

We have previously identified flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic aging. The aim the present study was to investigate role FMO5 in glucose homeostasis and impact diet gut flora on phenotype mice which Fmo5 gene has been disrupted (Fmo5-/- mice). In comparison with wild-type (WT) counterparts, Fmo5-/- are resistant age-related changes maintain higher tolerance insulin sensitivity characteristic young animals. When fed high-fat diet, they protected against weight gain reduction sensitivity. is independent microbiome determined solely by host genotype. characteristics similar those germ-free mice, indicating that plays sensing or responding bacteria. WT mucosal epithelium gastrointestinal tract where it induced response diet. fewer colonic goblet cells, differ production hormone resistin-like molecule βFmo5-/- lower concentrations tumor necrosis factor α plasma complement component 3 epididymal white adipose tissue, indicative improved inflammatory tone. Our results implicate body disposal and, thus, identify potential novel therapeutic target for obesity resistance.