Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model

• DOI: 10.1124/jpet.107.129551
• Publication Date: 2007-08-25T01:15:41Z
• Authors: Inna Vulih-Shultzman; Albert Pinhasov; Shmuel Mandel; Nikolaos Grigoriadis; Olga Touloumi; Zipora Pittel; Illana Gozes
• Keywords: Snippet; Nap; Hyperphosphorylation; Tau protein

Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate essential genes. Because complete ADNP deficiency is embryonic lethal, the outcome of partial was examined. ADNP(+/-) mice exhibited cognitive deficits, significant increases in phosphorylated tau, tangle-like structures, and neurodegeneration compared ADNP(+/+) mice. Increased tau hyperphosphorylation known cause memory impairments neurodegenerative diseases associated tauopathies, including most prevalent Alzheimer's disease. The current results suggest that an for brain function plays a role normal performance. ADNP-deficient offer ideal paradigm evaluation enhancers. NAP (NAPVSIPQ) peptide derived from microtubules provides potent neuroprotection. treatment partially ameliorated deficits reduced currently phase II clinical trials assessing effects on mild impairment.