β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β1 and β2 Adrenergic Receptors

• DOI: 10.1124/jpet.112.193615
• Publication Date: 2012-05-17T17:18:37Z
• Authors: Oliver Vranjkovic; Shona Hang; David A. Baker; John R. Mantsch
• Keywords: Adrenergic antagonist; Knockout mouse; Conditioned place preference

Stress can trigger the relapse of drug use in recovering cocaine addicts and reinstatement rodent models through mechanisms that may involve norepinephrine release β-adrenergic receptor activation. The present study examined role subtypes stressor-induced extinguished cocaine-induced (15 mg/kg i.p.) conditioned place preference mice. Forced swim (6 min at 22°C) stress or activation central noradrenergic neurotransmission by administration selective α₂ adrenergic antagonist 2-[(4,5-dihydro-1<i>H</i>-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1<i>H</i>-isoindole (BRL-44,408) (10 induced wild-type, but not β- receptor-deficient <i>Adrb1</i>/<i>Adrb2</i> double-knockout, In contrast, resulted both wild-type knockout Stress-induced probably involved β₂ receptors. -(isopropylamino)-1-[(7-methyl-4-indanyl)oxy]butan-2-ol (ICI-118,551) (1 2 blocked forced BRL-44,408, whereas nonselective agonist isoproterenol (2 4 receptor-selective clenbuterol reinstatement. swim-induced, BRL-44,408-induced, was also a high (20 mg/kg) low dose β₁ betaxolol, isoproterenol-induced pretreatment with either ICI-118,551 suggesting potential cooperative for receptors stress-induced Overall, these findings suggest targeting represent promising pharmacotherapeutic strategy preventing relapse, particularly whose is related.