Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase

• DOI: 10.1126/sciadv.1500112
• Publication Date: 2015-07-18T03:15:43Z
• Authors: Kristen M. Lorentz; Stephan Kontos; Giacomo Diaceri; Hugues Henry; Jeffrey A. Hubbell
• Keywords: 0303 health sciences; 03 medical and health sciences; 616; 610; Research Articles; 3. Good health

Humoral immune tolerance to the therapeutic enzyme E. coli l -asparaginase was induced by engineering the enzyme for in vivo erythrocyte binding.