The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment
PTEN
indoleamine 2,3-dioxygenase
SciAdv r-articles
610
Tregs
Regulatory T cells
Cancer Immunotherapy
3. Good health
03 medical and health sciences
0302 clinical medicine
tumor microenvironment
tumor immunology
14. Life underwater
Research Articles
DOI:
10.1126/sciadv.1500845
Publication Date:
2015-11-07T04:09:27Z
AUTHORS (15)
ABSTRACT
Tumors depend on a specialized pathway of regulatory T cell activation to create their immunosuppressive microenvironment, which can be blocked by inhibiting PTEN phosphatase.
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