The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment

• DOI: 10.1126/sciadv.1500845
• Publication Date: 2015-11-07T04:09:27Z
• Authors: Madhav D. Sharma; Rahul Shinde; Tracy L. McGaha; Lei Huang; Rikke B. Holmgaard; Jedd D. Wolchok; Mario R. Mautino; Esteban Celis; Arlene H. Sharpe; Loise M. Francisco; Jonathan D. Powell; Hideo Yagita; Andrew L. Mellor; Bruce R. Blazar; David H. Munn
• Keywords: PTEN; indoleamine 2,3-dioxygenase; SciAdv r-articles; 610; Tregs; Regulatory T cells; Cancer Immunotherapy; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; tumor microenvironment; tumor immunology; 14. Life underwater; Research Articles

Tumors depend on a specialized pathway of regulatory T cell activation to create their immunosuppressive microenvironment, which can be blocked by inhibiting PTEN phosphatase.