The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment
PTEN
indoleamine 2,3-dioxygenase
SciAdv r-articles
610
Tregs
Regulatory T cells
Cancer Immunotherapy
3. Good health
03 medical and health sciences
0302 clinical medicine
tumor microenvironment
tumor immunology
14. Life underwater
Research Articles
DOI:
10.1126/sciadv.1500845
Publication Date:
2015-11-07T04:09:27Z
AUTHORS (15)
ABSTRACT
The tumor microenvironment is profoundly immunosuppressive. We show that multiple types create intratumoral immune suppression driven by a specialized form of regulatory T cell (Treg) activation dependent on the PTEN (phosphatase and tensin homolog) lipid phosphatase. acted to stabilize Tregs in tumors, preventing them from reprogramming into inflammatory effector cells. In mice with Treg-specific deletion PTEN, tumors grew slowly, were inflamed, could not an immunosuppressive microenvironment. normal mice, exposure apoptotic cells rapidly elicited PTEN-expressing Tregs, PTEN-deficient unable maintain tolerance wild-type large established pharmacologic inhibition after chemotherapy or immunotherapy reconfigured microenvironment, changing it suppressive milieu, underwent rapid regression. Thus, milieu must be actively maintained, become susceptible attack if pathway disrupted.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (68)
CITATIONS (157)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....