TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1

• DOI: 10.1126/sciadv.1501290
• Publication Date: 2016-04-02T04:05:46Z
• Authors: Mohammad B. Hossain; Rehnuma Shifat; David G. Johnson; Mark T. Bedford; Konrad R. Gabrusi...; Nahir Cortes-Sant...; Xuemei Luo; Zhimin Lu; Ravesanker Ezhila...; Erik P. Sulman; Hong Jiang; Shawn S. C. Li; Frederick F. Lang; Jessica Tyler; Mien-Chie Hung; Juan Fueyo; Candelaria Gomez-...
• Keywords: 570; 0303 health sciences; DNA End-Joining Repair; 610; Proto-Oncogene Mas; Radiation Tolerance; Receptor, TIE-2; Histones; Protein Transport; 03 medical and health sciences; Cell Line, Tumor; Radiation, Ionizing; Humans; Tyrosine; Angiotensin I; Proto-Oncogene Proteins c-abl; Research Articles; DNA Damage; Protein Binding

Membrane-bound enzyme relocates to the cell nucleus to modify chromatin, inducing cancer resistance to radiotherapy.