A conducting polymer with enhanced electronic stability applied in cardiac models

• DOI: 10.1126/sciadv.1601007
• Publication Date: 2016-12-01T03:40:25Z
• Authors: Damia Mawad; Catherine Mansfield; Antonio Lauto; Filippo Perbellini; Geoffrey W. Nelson; Joanne Tonkin; Sean O. Bello; Damon J. Carrad; Adam P. Micolich; Mohd M. Mahat; Jennifer Furman; David Payne; Alexander R. Lyon; J. Justin Gooding; Sian E. Harding; Cesare M. Terracc...; Molly M. Stevens
• Keywords: Ex vivo

Electrically active constructs can have a beneficial effect on electroresponsive tissues, such as the brain, heart, and nervous system. Conducting polymers (CPs) are being considered components of these because their intrinsic electroactive flexible nature. However, clinical application has been largely hampered by short operational time due to decrease in electronic properties. We show that, immobilizing dopant conductive scaffold, we prevent its electric deterioration. grew polyaniline (PANI) doped with phytic acid surface chitosan film. The strong chelation between led patch retained electroactivity, low resistivity (35.85 ± 9.40 kilohms per square), oxidized form after 2 weeks incubation physiological medium. Ex vivo experiments revealed that nature an immediate electrophysiology heart. Preliminary showed does not induce proarrhythmogenic activities Our findings set foundation for design electronically stable CP-based scaffolds. This provides robust system could be used at interface tissue better understand interaction materials tissues.