Ceftazidime-avibactam has potent sterilizing activity against highly drug-resistant tuberculosis

• DOI: 10.1126/sciadv.1701102
• Publication Date: 2017-08-31T01:10:26Z
• Authors: Devyani Deshpande; Shashikant Srivas...; Moti Chapagain; Gesham Magombedze; Katherine R. Martin; Kayle N. Cirrincione; Pooi S. Lee; Thearith Koeuth; Keertan Dheda; Tawanda Gumbo
• Keywords: 0301 basic medicine; Dose-Response Relationship, Drug; Extensively Drug-Resistant Tuberculosis; Age Factors; Antitubercular Agents; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Ceftazidime; Cell Line; 3. Good health; Drug Combinations; 03 medical and health sciences; Treatment Outcome; Mutation; Tuberculosis, Multidrug-Resistant; Animals; Humans; Azabicyclo Compounds; Research Articles; Genome, Bacterial

Ceftazidime-avibactam is highly efficacious against extensive- and multidrug-resistant strains of Mycobacterium tuberculosis .