Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury

• DOI: 10.1126/sciadv.aaq0597
• Publication Date: 2018-04-04T21:15:55Z
• Authors: Isma Liza Mohd Isa; Sunny A. Abbah; Michelle Kilcoyne; Daisuke Sakai; Peter Dockery; David P. Finn; Abhay Pandit
• Keywords: Intervertebral Disc

Painful intervertebral disc degeneration is mediated by inflammation that modulates glycosylation and induces hyperinnervation sensory sensitization, which result in discogenic pain. Hyaluronic acid (HA) used as a therapeutic biomaterial can reduce pain, but the effects of HA therapy on pain associated with have not been previously determined. We describe novel rat model induced injury, validation phenotype morphine treatment. Using this model, we assessed efficacy hydrogel for alleviation demonstrating it reduced nociceptive behavior, an effect down-regulation nociception markers inhibition hyperinnervation. Furthermore, altered modulated key inflammatory regulatory signaling pathways, resulting attenuation regulation matrix components. Our results suggest promising clinical candidate treatment back caused degenerated discs.