A persulfidation-based mechanism controls aquaporin-8 conductance

• DOI: 10.1126/sciadv.aar5770
• Publication Date: 2018-05-02T18:15:23Z
• Authors: Stefano Bestetti; Iria Medraño-Fern...; Mauro Galli; Michela Ghitti; Gerd P. Bienert; Giovanna Musco; Andrea Orsi; Anna Rubartelli; Roberto Sitia
• Keywords: 0303 health sciences; Cell Membrane Permeability; Cell Membrane; Molecular Conformation; Biological Transport; Hydrogen Peroxide; Sulfides; Aquaporins; Models, Biological; 03 medical and health sciences; Stress, Physiological; Amino Acid Sequence; Hydrogen Sulfide; Oxidation-Reduction; Research Articles

A two-step posttranslational modification of AQP8 provides a mechanism regulating plasma membrane H 2 O 2 conductance.