Mannan-induced Nos2 in macrophages enhances IL-17–driven psoriatic arthritis by innate lymphocytes

• DOI: 10.1126/sciadv.aas9864
• Publication Date: 2018-05-16T18:15:14Z
• Authors: Jianghong Zhong; Tatjana Scholz; Anthony C. Y. Yau; Simon Guerard; Ulrike Hüffmeier; Harald Burkhardt; Rikard Holmdahl
• Keywords: 0301 basic medicine; Lipopolysaccharide Receptors; 610; Gene Expression; Nitric Oxide Synthase Type II; Mice, Transgenic; Nitric Oxide; Mannans; Mice; 03 medical and health sciences; T-Lymphocyte Subsets; Interleukin-1alpha; Animals; Humans; ddc:610; Lymphocytes; Research Articles; Alleles; ddc:610; 0303 health sciences; Macrophages; Arthritis, Psoriatic; Interleukin-17; Immunity, Innate; 3. Good health; Disease Models, Animal; 13. Climate action

Inducible nitric oxide from skin macrophages promotes IL-17 release and psoriatic arthritis by innate lymphoid cells.