Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
0301 basic medicine
Amyloid beta-Peptides
Microfluidics
Peptide Fragments
Recombinant Proteins
Kinetics
Protein Aggregates
03 medical and health sciences
Clusterin
Alzheimer Disease
Humans
Research Articles
Protein Binding
DOI:
10.1126/sciadv.aau3112
Publication Date:
2019-04-17T23:16:01Z
AUTHORS (12)
ABSTRACT
Chaperone regulation of individual microscopic events in Aβ42 aggregation reveals the nature of active sites on amyloid fibrils.
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