Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

0301 basic medicine Amyloid beta-Peptides Microfluidics Peptide Fragments Recombinant Proteins Kinetics Protein Aggregates 03 medical and health sciences Clusterin Alzheimer Disease Humans Research Articles Protein Binding
DOI: 10.1126/sciadv.aau3112 Publication Date: 2019-04-17T23:16:01Z
ABSTRACT
Chaperone regulation of individual microscopic events in Aβ42 aggregation reveals the nature of active sites on amyloid fibrils.
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