Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

• DOI: 10.1126/sciadv.aau3112
• Publication Date: 2019-04-17T23:16:01Z
• Authors: Tom Scheidt; Urszula Łapińska; Janet R. Kumita; Daniel R. Whiten; David Klenerman; Mark R. Wilson; Samuel I. A. Cohen; Sara Linse; Michele Vendruscolo; Christopher M. Do...; Tuomas P. J. Knowles; Paolo Arosio
• Keywords: 0301 basic medicine; Kinetics; Protein Aggregates; 03 medical and health sciences; Amyloid beta-Peptides; Clusterin; Alzheimer Disease; Microfluidics; Humans; Research Articles; Peptide Fragments; Recombinant Proteins; Protein Binding

Chaperone regulation of individual microscopic events in Aβ42 aggregation reveals the nature of active sites on amyloid fibrils.