Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

• DOI: 10.1126/sciadv.aau3333
• Publication Date: 2019-01-24T00:14:31Z
• Authors: Stephen S. Dominy; Casey Lynch; Florian Ermini; Malgorzata Benedyk; Agata Marczyk; Andrei Konradi; Mai Nguyen; Ursula Haditsch; Debasish Raha; Christina Griffin; Leslie J. Holsinger; Shirin Arastu-Kapur; Samer Kaba; Alexander Lee; Mark I. Ryder; Barbara Potempa; Piotr Mydel; Annelie Hellvard; Karina Adamowicz; Hatice Hasturk; Glenn D. Walker; Eric C. Reynolds; Richard L. M. Faull; Maurice A. Curtis; Mike Dragunow; Jan Potempa
• Keywords: Causation

Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.