RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

• DOI: 10.1126/sciadv.aav0443
• Publication Date: 2018-11-21T19:15:06Z
• Authors: J.-M. Heo; A. Ordureau; S. Swarup; J. A. Paulo; K. Shen; D. M. Sabatini; J. W. Harper
• Keywords: 0301 basic medicine; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Mitophagy; Ubiquitination; Vesicular Transport Proteins; Autophagy-Related Proteins; Membrane Proteins; rab7 GTP-Binding Proteins; Protein Serine-Threonine Kinases; Mitochondria; 03 medical and health sciences; rab GTP-Binding Proteins; Proto-Oncogene Proteins; Humans; Phosphorylation; Protein Kinases; Research Articles; HeLa Cells

TBK1 phosphorylates RAB7A-S72 to support multiple downstream steps in PARKIN-dependent mitophagy.