SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

• DOI: 10.1126/sciadv.aav1118
• Publication Date: 2019-03-27T23:17:57Z
• Authors: Ming Tang; Zhiming Li; Chaohua Zhang; Xiaopeng Lu; Bo Tu; Ziyang Cao; Yinglu Li; Yongcan Chen; Lu Jiang; Hui Wang; Lina Wang; Jiadong Wang; Baohua Liu; Xingzhi Xu; Haiying Wang; Wei-Guo Zhu
• Keywords: 0301 basic medicine; DNA Repair; Acetylation; Ataxia Telangiectasia Mutated Proteins; HCT116 Cells; Chromatin; Protein Phosphatase 2C; 03 medical and health sciences; HEK293 Cells; Cell Line, Tumor; Mutation; Humans; Sirtuins; DNA Breaks, Double-Stranded; RNA Interference; Phosphorylation; Research Articles; DNA Damage

SIRT7 plays a critical role in dissembling and deactivating ATM when DNA damage repair is completed.