No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication
Compartmentalization (fire protection)
Replication
ANTIRETROVIRAL AGENTS
DOI:
10.1126/sciadv.aav2045
Publication Date:
2019-09-25T23:16:30Z
AUTHORS (24)
ABSTRACT
HIV persistence during combination antiretroviral therapy (cART) is the principal obstacle to cure. Mechanisms responsible for remain uncertain; infections may be maintained by and clonal expansion of infected cells or ongoing replication in anatomic locations with poor penetration. These mechanisms require different strategies eradication, determining their contributions essential. We used phylogenetic approaches investigate, at DNA level, populations blood, lymphoid, other tissues obtained colonoscopy autopsy individuals who were on cART 8 16 years. found no evidence compartmentalization HIV; we did detect that present before cART. Long-term persistence, not replication, primarily maintaining HIV. HIV-infected when initiated represent only identifiable source appropriate focus eradication.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (55)
CITATIONS (74)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....