Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism

• DOI: 10.1126/sciadv.aax6208
• Publication Date: 2020-01-04T00:15:54Z
• Authors: Su-Ling Zeng; Shang-Zhen Li; Ping-Ting Xiao; Yuan-Yuan Cai; Chu Chu; Bai-Zhong Chen; Ping Li; Jing Li; E-Hu Liu
• Keywords: Gut microbiome; Microbial Metabolism; Metabolic pathway

Metabolic syndrome (MetS) is intricately linked to dysregulation of gut microbiota and host metabolomes. Here, we first find that a purified citrus polymethoxyflavone-rich extract (PMFE) potently ameliorates high-fat diet (HFD)-induced MetS, alleviates dysbiosis, regulates branched-chain amino acid (BCAA) metabolism using 16S rDNA amplicon sequencing metabolomic profiling. The metabolic protective effects PMFE are dependent, as demonstrated by antibiotic treatment fecal microbiome transplantation (FMT). modulation altered BCAA levels in the serum feces, which were significantly associated with features actively responsive therapeutic interventions PMFE. Notably, greatly enriched commensal bacterium Bacteroides ovatus, gavage B. ovatus reduced concentrations alleviated MetS HFD mice. may be used prebiotic agent attenuate target-specific microbial species have unique promise for diseases.