Disordered chromatin packing regulates phenotypic plasticity

• DOI: 10.1126/sciadv.aax6232
• Publication Date: 2020-01-09T00:15:19Z
• Authors: Ranya K. A. Virk; Wenli Wu; Luay M. Almassalha; Greta M. Bauer; Yue Li; David VanDerway; Jane Frederick; Di Zhang; Adam Eshein; Hemant K. Roy; Igal Szleifer; Vadim Backman
• Keywords: 0301 basic medicine; 0303 health sciences; Transcription, Genetic; Macromolecular Substances; Adaptation, Physiological; Models, Biological; Survival Analysis; Chromatin; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Cell Line, Tumor; Humans; Research Articles

The CPMC model demonstrates the regulatory role of chromatin’s physical structure on transcription and phenotypic plasticity.