Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity

• DOI: 10.1126/sciadv.aax8352
• Publication Date: 2019-09-11T23:16:06Z
• Authors: Timothy D. Heden; Jordan M. Johnson; Patrick J. Ferrara; Hiroaki Eshima; Anthony R. P. Ver...; Edward J. Wentzler; Piyarat Siripoksup; Tara M. Narowski; Chanel B. Coleman; Chien-Te Lin; Terence E. Ryan; Paul T. Reidy; Lisandra E. de Ca...; Courtney M. Karner; Charles F. Burant; J. Alan Maschek; James E. Cox; Douglas G. Mashek; Gabrielle Kardon; Sihem Boudina; Tonya N. Zeczycki; Jared Rutter; Saame Raza Shaikh; Jean E. Vance; Micah J. Drummond; P. Darrell Neufer; Katsuhiko Funai
• Keywords: Male; Mice, Knockout; 0301 basic medicine; Exercise Tolerance; Carboxy-Lyases; Phosphatidylethanolamines; Mitochondria; Mice, Inbred C57BL; Mitochondrial Proteins; Myoblasts; Mice; Oxidative Stress; 03 medical and health sciences; Oxygen Consumption; Physical Conditioning, Animal; Mitochondrial Membranes; Animals; Female; Muscle, Skeletal; Reactive Oxygen Species; Research Articles; Muscle Contraction

Mitochondrial membrane lipids adapt to exercise or disuse, underscoring an essential role for PE in energy transduction.