SpCas9 activity prediction by DeepSpCas9, a deep learning–based model with high generalization performance

• DOI: 10.1126/sciadv.aax9249
• Publication Date: 2019-11-07T00:15:02Z
• Authors: Hui Kwon Kim; Younggwang Kim; Sungtae Lee; Seonwoo Min; Jung Yoon Bae; Jae Woo Choi; Jinman Park; Dongmin Jung; Sungroh Yoon; Hyongbum Henry Kim
• Keywords: Gene Editing; 0301 basic medicine; Internet; Reproducibility of Results; 004; 03 medical and health sciences; Deep Learning; CRISPR-Associated Protein 9; Mutation; Humans; CRISPR-Cas Systems; Research Articles; RNA, Guide, Kinetoplastida

A deep learning–based model predicts activity of a widely used genome editing tool in a highly accurate manner.