Physical and data structure of 3D genome

• DOI: 10.1126/sciadv.aay4055
• Publication Date: 2020-01-11T00:14:24Z
• Authors: Kai Huang; Yue Li; Anne R. Shim; Ranya K. A. Virk; Vasundhara Agrawal; Adam Eshein; Rikkert J. Nap; Luay M. Almassalha; Vadim Backman; Igal Szleifer
• Keywords: Genome; Imaging, Three-Dimensional; Models, Genetic; A549 Cells; Spectrum Analysis; Humans; Nucleic Acid Conformation; Research Articles; Algorithms; Chromatin

With the textbook view of chromatin folding based on 30-nm fiber being challenged, it has been proposed that interphase DNA an irregular 10-nm nucleosome polymer structure whose philosophy is unknown. Nevertheless, experimental advances suggest this packing associated with many nontrivial physical properties are puzzling from a physics point view. Here, we show reconciliation these exotic necessitates modularizing three-dimensional genome into tree data structures top of, and in striking contrast to, linear topology double helix. These functional modules need to be connected isolated by open backbone results porous heterogeneous quasi-self-similar manner, as revealed our electron optical imaging. Our multiscale theoretical existence higher-order universal principles for disordered avoid entanglement fulfill its biological functions.