Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes

• DOI: 10.1126/sciadv.aay5736
• Publication Date: 2020-02-20T00:19:52Z
• Authors: Eiji Yamamoto; Jan Domański; Fiona B. Naughton; Robert B. Best; Antreas C. Kalli; Phillip J. Stansfeld; Mark S. P. Sansom
• Keywords: 0301 basic medicine; 0303 health sciences; Binding Sites; Protein Conformation; QH; Cell Membrane; Receptors, Cytoplasmic and Nuclear; Pleckstrin Homology Domains; Models, Theoretical; Molecular Dynamics Simulation; Phosphatidylinositols; QP; Lipids; 3. Good health; Membrane Lipids; 03 medical and health sciences; Protein Interaction Domains and Motifs; Research Articles; Algorithms; Protein Binding

Molecular simulations reveal that multiple lipid interactions are needed for high-affinity binding of protein domains to membranes.