Streptavidin/biotin: Tethering geometry defines unbinding mechanics

• DOI: 10.1126/sciadv.aay5999
• Publication Date: 2020-03-25T23:15:14Z
• Authors: Steffen M. Sedlak; Leonard C. Schendel; Hermann E. Gaub; Rafael C. Bernardi
• Keywords: Models, Molecular; 0301 basic medicine; Structure-Activity Relationship; 03 medical and health sciences; Chemical Phenomena; Macromolecular Substances; Molecular Conformation; Biotin; Streptavidin; Microscopy, Atomic Force; Research Articles; Protein Binding

Single-molecule force spectroscopy reveals how the mechanical stability of a widely used biomolecular complex varies fourfold.