Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury

• DOI: 10.1126/sciadv.aay6314
• Publication Date: 2020-03-18T23:19:28Z
• Authors: Jörn Karhausen; Hae Woong Choi; Krishna Rao Maddi...; Joseph P. Mathew; Qing Ma; Yacine Boulaftali; Robert Hugh Lee; Wolfgang Bergmeier; Soman N. Abraham
• Keywords: Blood Platelets; Inflammation; 570; 0303 health sciences; 610; Platelet Activation; Cell Degranulation; Rats; 03 medical and health sciences; Organ Specificity; Animals; Disease Susceptibility; Mast Cells; Platelet Activating Factor; Research Articles

Activated platelets cause microvascular inflammation via direct activation of perivascular mast cells.