Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification

• DOI: 10.1126/sciadv.aay9526
• Publication Date: 2020-05-20T23:59:43Z
• Authors: Yangwu Chen; Weiliang Shen; Chenqi Tang; Jiayun Huang; Chunmei Fan; Zi Yin; Yejun Hu; Weishan Chen; Hongwei Ouyang; Yiting Zhou; Zhengwei Mao; Xiao Chen
• Keywords: Sirolimus; 0301 basic medicine; Mice; 03 medical and health sciences; Delayed-Action Preparations; Ossification, Heterotopic; TOR Serine-Threonine Kinases; Animals; Collagen; Research Articles; 3. Good health; 12. Responsible consumption

We revealed the importance of mTOR in tendon HO and established a drug delivery system that targets pathological collagen.