Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes

• DOI: 10.1126/sciadv.aaz1580
• Publication Date: 2020-03-11T23:14:35Z
• Authors: Patrick Han; Douglas Hanlon; Najla Arshad; Jung Seok Lee; Kazuki Tatsuno; Alp Yurter; Eve Robinson; Renata Filler; Olga Sobolev; Christine Cote; Felix Rivera-Molina; Derek Toomre; Tarek Fahmy; Richard Edelson
• Keywords: Blood Platelets; Antigen Presentation; Membrane Glycoproteins; T-Lymphocytes; NF-kappa B; Cell Differentiation; Mice, Transgenic; Dendritic Cells; Monocytes; 3. Good health; Mice; P-Selectin; 03 medical and health sciences; 0302 clinical medicine; Antigens, Neoplasm; Animals; Calcium Signaling; Research Articles

Platelet-monocyte “adhesion synapse” initiates physiologic biogenesis of cross-presenting dendritic cells.