SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1

• DOI: 10.1126/sciadv.aaz2590
• Publication Date: 2020-07-24T23:15:13Z
• Authors: Nicolás G. Simonet; Joshua K. Thackray; Berta N. Vazquez; Alessandro Ianni; Maria Espinosa-Al...; Julia Morales-San...; Sarah Hurtado-Bagès; Eduard Sabidó; Marcus Buschbeck; Jay Tischfield; Carolina De La Torre; Manel Esteller; Thomas Braun; Mireia Olivella; Lourdes Serrano; Alejandro Vaquero
• Keywords: 0301 basic medicine; STRESS; Trastorns del metabolisme; Starvation response; PROTEIN; Homeòstasi; Glucose homeostasis; ACTIVATION; 03 medical and health sciences; RNA-POLYMERASE-I; Expression profile; Second messenger; CALORIE RESTRICTION; BINDING; Homeostasis; Intergenic regions; Metabolic stress; Calorie restriction; Research Articles; 2. Zero hunger; PURIFICATION; NAD; Estrès (Fisiologia); Disorders of metabolism; SIRTUINS; AUTOPHAGY; Stress (Physiology); ADP-ribosylation

SirT7 is a dual enzyme that regulates energy deprivation response through a functional interaction with histone variant mH2A1.