Noninvasive imaging and quantification of bile salt hydrolase activity: From bacteria to humans

• DOI: 10.1126/sciadv.aaz9857
• Publication Date: 2021-02-03T20:33:42Z
• Authors: Pavlo V. Khodakiv...; Christian L. Lauber; Aleksey Yevtodiyenko; Arkadiy A. Bazhin; Stephen Bruce; Tamar Ringel-Kulka; Yehuda Ringel; Bertrand Bétrisey; Joana Torres; Jianzhong Hu; Chieh Jason Chou; Elena A. Goun
• Keywords: 0303 health sciences; Bacteria; Amidohydrolases/analysis; Amidohydrolases/chemistry; Animals; Bacteria; Bile Acids and Salts; Gastrointestinal Microbiome/physiology; Humans; Luminescent Measurements/methods; Mice; Prebiotics; Amidohydrolases; Gastrointestinal Microbiome; 3. Good health; Bile Acids and Salts; Mice; 03 medical and health sciences; Prebiotics; Luminescent Measurements; Animals; Humans; Research Articles

Novel optical probes allow quantification of bile salt hydrolase activity in bacteria, clinical fecal samples, mice, and humans.